Dr.'s Newport and Veech are leading the fight to get a new Alzheimer's treatment into the mainstream.
First, this is NOT a treatment for Alzheimer's Disease (AD). Rather it is a way to alleviate some of the most critical symptoms - i.e. loss of mental capacity.
The entire basis of the treatment is linked to the fact that the physical changes in the brain caused by AD also make the brain cells (neurons) incapable of using insulin to transport sugar into the cell and the cells cease to function.
However while the cells can no longer use the glucose energy source, they can use ketone bodies for fuel bypassing the metabolic block which prevents them from using glucose.
When AD patients receive high doses of ketones the brain cells arfe no longer starved and begin to work again, sometimes amazingly quickly and well - showing improvements (in the approximately half of the cases where it works) within a few hours.
One way to increase the ketones in the bloodstream is to change to a diet which switches the body's metabolism from running on glucose from carbohydrates to one which burns body fat. Essentially the South Beach Diet.
-------------------------- Information from Alzheimers Dement. 2015 Jan;11(1):99-103. doi: 10.1016/j.jalz.2014.01.006. Epub 2014 Oct 7. Newport MT1, VanItallie TB2, Kashiwaya Y3, King MT4, Veech RL5.
KME-induced hyperketonemia is robust, convenient, and safe, and the ester can be taken as an oral supplement without changing the habitual diet."
First, this is NOT a treatment for Alzheimer's Disease (AD). Rather it is a way to alleviate some of the most critical symptoms - i.e. loss of mental capacity.
The entire basis of the treatment is linked to the fact that the physical changes in the brain caused by AD also make the brain cells (neurons) incapable of using insulin to transport sugar into the cell and the cells cease to function.
However while the cells can no longer use the glucose energy source, they can use ketone bodies for fuel bypassing the metabolic block which prevents them from using glucose.
When AD patients receive high doses of ketones the brain cells arfe no longer starved and begin to work again, sometimes amazingly quickly and well - showing improvements (in the approximately half of the cases where it works) within a few hours.
One way to increase the ketones in the bloodstream is to change to a diet which switches the body's metabolism from running on glucose from carbohydrates to one which burns body fat. Essentially the South Beach Diet.
Several people including Dr. Veech are working on supplements which produce a "therapeutic hyperketonemia" through the use of oral ingestion (eating) a strong ketogenic agent or ketone monoester (KME).
Trials of this treatment show, "The patient improved markedly in mood, affect, self-care, and cognitive and daily activity performance. The KME was well tolerated throughout the 20-month treatment period. Cognitive performance tracked plasma β-hydroxybutyrate concentrations, with noticeable improvements in conversation and interaction at the higher levels, compared with predose levels.
CONCLUSION:
A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer's disease.
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Many people go on a zero carb diet for two weeks or until your keto strips show your metabolism has switched from burning sugar to burning fat. You usually lose about 10 lbs pretty quickly.
This is actually a great diet, you eat eggs, bacon, pork, fish, lobster, butter, any cheese, cream, ice cream (homemade with sucralose (Splenda)), coffee, tea, almost anything except grains and tubers. Some veggies after the switch.but not most of them.
Coconut oil/butter is a good substitute for cooking oils and baking - it has very high levels of ketones.
You would think this meat and fat diet would cause your cholesterol to soar, but it actually lowers most people's cholesterol because cholesterol is just another fat which the body is now burning for energy.
The full text of the report is found at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300286/
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