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Thursday, August 16, 2018

New Sepsis Test Developed by UK MoD

With two revolutionary treatments for sepsis as described in other posts here in CMN, it becomes even more important to diagnose the deadly condition ASAP if ONLY so patient advocates have enough time to find a doctor who will listen to them about the new discoveries already saving lives in the few locations where they are being used.

Survival rates for sepsis aka blood poisoning drop nearly 10 percent each hour it goes undiagnosed and untreated.

The current test takes up to several days to give a full diagnosis of a disease which kills at least 5 million each year out of the approximately 30 million who contract it each year. 

That's more than bowel, breast, and prostate cancer combined.

Even more alarming is the fact that sepsis cases are increasing 10% each year.

In the UK it is believed to cost nearly £15 billion per year.

Now the United Kingdom's Ministry of Defense has announced a new rapid test to confirm sepsis, permitting faster treatment. 

Scientists at the Defence Science and Technology Laboratory (Dstl) in the UK have come up with a biomarker test which can prove the existence of a sepsis infection even before symptoms appear. The test is 97% accurate, having been studied for more than a decade.

Dr Roman Lukaszewski is the lead Dstl scientist.

Dstl site.

https://www.gov.uk/government/news/new-test-for-sepsis-could-improve-survival-rates-thanks-to-dstl-scientists

Friday, August 10, 2018

Vitamin D delays or prevents diabetes onset

My book on Vitamin D looked at the powerful medical journal evidence that Vitamin D-3 can prevent or cure malignant melanoma but the latest information expands the powerful role of Vitamin D to at least delaying the onset of Typ[e 2 diabetes.

Dodical jes Vitamin D-3 Cure Malignant Melanoma?: How about curry? VITAL information directly from meournals. (Collected Works: John A. McCormick Book 2) Kindle Edition

The mechanism of protection against melanoma cancers is not clear but the way Vitamin D helps prevent Type 2 diabetes is actually clear, the vitamin protects against β cell dysfunction

β cells have a profound effect on insulin sensitivity which is the real problem with diabetes.

Summary from Cell: "A primary cause of disease progression in type 2 diabetes (T2D) is β cell dysfunction due to inflammatory stress and insulin resistance. However, preventing β cell exhaustion under diabetic conditions is a major therapeutic challenge. Here, we identify the vitamin D receptor (VDR) as a key modulator of inflammation and β cell survival. Alternative recognition of an acetylated lysine in VDR by bromodomain proteins BRD7 and BRD9 directs association to PBAF and BAF chromatin remodeling complexes, respectively. Mechanistically, ligand promotes VDR association with PBAF to effect genome-wide changes in chromatin accessibility and enhancer landscape, resulting in an anti-inflammatory response. Importantly, pharmacological inhibition of BRD9 promotes PBAF-VDR association to restore β cell function and ameliorate hyperglycemia in murine T2D models. These studies reveal an unrecognized VDR-dependent transcriptional program underpinning β cell survival and identifies the VDR:PBAF/BAF association as a potential therapeutic target for T2D."
https://www.cell.com/cell/abstract/S0092-8674(18)30506-3
      Arnush, M.Heitmeier, M.R.Scarim, A.L.Marino, M.H.Manning, P.T.Corbett, J.A.
      IL-1 produced and released endogenously within human islets inhibits beta cell function.
      J. Clin. Invest. 1998; 102: 516-526
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Illustration from Cell.com