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Monday, September 17, 2018

Blood Pressure medicine recalled due to contamination from Chinese source


Known as HCTZ Valsartan, or under other names by various generic manufacturers, the FDA and other drug watchdogs in Europe and Canada have reported that the Chinese pharmaceutical company making the raw materials are shipping contaminated drugs containing one or even two kinds of carcinogens.

FDA UPDATE https://www.fda.gov/drugs/drugsafety/ucm613916.htm

Here are links to the recalled drugs and also a list of those not recalled.

NOT recalled https://www.fda.gov/downloads/Drugs/DrugSafety/UCM615704.pdf

Under recall https://www.fda.gov/downloads/Drugs/DrugSafety/UCM615703.pdf

Teva
Acativas (Teva)
AvKARE also Teva
Princeton/Solco and RemedyPrepack
AS Medication another Teva and Solco
BRYANT another Teva
 HJ Harkins another Solco Princeton
Northwind
NuCare
Preferred
Torrent






Sunday, September 16, 2018

Background - More Aspirin Studies Early Study Inconclusive

See next blog posting for the new studies, this is background.

As with many medical studies the results of studies on men and women and low dose aspirin are confusing and sometimes contradictory but remember that the newest studies published in peer-reviewed journals such as the NEJM or The Lancet, Nature, and Science, are built on the information obtained from the earlier studies and are therefore likely to be correct even when they contradict the older studies.

Studies of the results for women and girls are especially important because until recently most studies were conducted on men and only in recent years has it been shown that the results for women can vary greatly from those for men. That one chromosome is very important.

A randomized trial published in the NEJM in 2005 found only a tiny, 9% improvement in preventing initial heart attacks in women so the new studies should be considered especially important for women when considering the proven risks vs the small potential benefits of low dose aspirin therapy.

https://www.nejm.org/doi/full/10.1056/NEJMoa050613

Quoted from NEJM:

"BACKGROUND

Randomized trials have shown that low-dose aspirin decreases the risk of a first myocardial infarction in men, with little effect on the risk of ischemic stroke. There are few similar data in women.

METHODS

We randomly assigned 39,876 initially healthy women 45 years of age or older to receive 100 mg of aspirin on alternate days or placebo and then monitored them for 10 years for a first major cardiovascular event (i.e., nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes)."

and
"Although aspirin is effective in the treatment of acute myocardial infarction and in the secondary prevention of cardiovascular disease among both men and women,1 its use in primary prevention remains controversial. To date, five randomized trials involving 55,580 participants have evaluated aspirin in the primary prevention of cardiovascular disease.2-6 In aggregate, these trials indicate that, as compared with placebo, aspirin therapy was associated with a significant, 32 percent reduction in the risk of myocardial infarction, but the data on the risk of stroke and death from cardiovascular disease remains inconclusive.7Moreover, three of these trials evaluated men exclusively, and fewer than 180 of the 2402 vascular events occurred in women. Thus, at this time, the current recommendations for the use of aspirin in primary prevention in women are based on limited direct data from women" 

Low Dose Aspirin Not Helpful and Actually Dangerous say 3 NEJM published studies

Taking a low dose aspirin has been considered the standard of good health practice for decades to prevent the first heart attack in otherwise healthy people.

Unfortunately this common medical wisdom isn't actually supported by a lot of evidence and now the New England Journal of Medicine has published three studies with more than 20,000 participants showing that not only is this not a good way for people over 65 (and probably younger) to prevent a first heart attack.

Also, because aspirin, even low dose or "baby" aspirin (between about 80 mg and 300 mg) reduces the ability for blood to clot it can encourage bleeding in the brain.


Effect of Aspirin on Disability-free Survival in the Healthy Elderly  
J.J. McNeil and Others   
<http://response.nejm.org/t?ctl=45B57:82F864202E91A81197A27C9082BFE7BDF91BDD2A20A1D99A&uuid=10295107&dateTime=201809260000&key=wZxk%2FaDT8hj7YLGnnkqQUfeBvC5O%2Br%2FO5gm4%2FvQeP%2Fw%3D>   
Free Full Text | Comments

ORIGINAL ARTICLE

Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly  
J.J. McNeil and Others   
<http://response.nejm.org/t?ctl=45B58:82F864202E91A81197A27C9082BFE7BDF91BDD2A20A1D99A&uuid=10295107&dateTime=201809260000&key=wZxk%2FaDT8hj7YLGnnkqQUfeBvC5O%2Br%2FO5gm4%2FvQeP%2Fw%3D>   
Free Full Text

ORIGINAL ARTICLE

Effect of Aspirin on All-Cause Mortality in the Healthy Elderly  
J.J. McNeil and Others   
<http://response.nejm.org/t?ctl=45B59:82F864202E91A81197A27C9082BFE7BDF91BDD2A20A1D99A&uuid=10295107&dateTime=201809260000&key=wZxk%2FaDT8hj7YLGnnkqQUfeBvC5O%2Br%2FO5gm4%2FvQeP%2Fw%3D>   
Free Full Text

Monday, August 20, 2018

Low carb AND high carb diets increase chance of early death - Lancet published study

A study of 15,000 adults age 45-64 in 4 US communities who were part of the Atherosclerosis Risk in Communities study between 1987 and 1989 and weren't on any extreme caloric diet, either high or low, was recently used as the basis of a follow up 25 years later.

By now there have been 6,283 deaths in the ARIC group but the study in The Lancet Public Health also looked at more than 400,000 people in other studies.

Those who had the lowest risk of mortality (death) from all causes were the ones who got about half of their calories from carbohydrates.

BOTH low carb <40% and high carb >70% diets resulted in greater risk of early death.

In addition, if the carbs were replaced by animal fat or animal protein the risk was also higher but if the carbs were replaced by plant-based oils or protein.

The study was recently published in The Lancet Public Health which is available online.

Thursday, August 16, 2018

New Sepsis Test Developed by UK MoD

With two revolutionary treatments for sepsis as described in other posts here in CMN, it becomes even more important to diagnose the deadly condition ASAP if ONLY so patient advocates have enough time to find a doctor who will listen to them about the new discoveries already saving lives in the few locations where they are being used.

Survival rates for sepsis aka blood poisoning drop nearly 10 percent each hour it goes undiagnosed and untreated.

The current test takes up to several days to give a full diagnosis of a disease which kills at least 5 million each year out of the approximately 30 million who contract it each year. 

That's more than bowel, breast, and prostate cancer combined.

Even more alarming is the fact that sepsis cases are increasing 10% each year.

In the UK it is believed to cost nearly £15 billion per year.

Now the United Kingdom's Ministry of Defense has announced a new rapid test to confirm sepsis, permitting faster treatment. 

Scientists at the Defence Science and Technology Laboratory (Dstl) in the UK have come up with a biomarker test which can prove the existence of a sepsis infection even before symptoms appear. The test is 97% accurate, having been studied for more than a decade.

Dr Roman Lukaszewski is the lead Dstl scientist.

Dstl site.

https://www.gov.uk/government/news/new-test-for-sepsis-could-improve-survival-rates-thanks-to-dstl-scientists

Friday, August 10, 2018

Vitamin D delays or prevents diabetes onset

My book on Vitamin D looked at the powerful medical journal evidence that Vitamin D-3 can prevent or cure malignant melanoma but the latest information expands the powerful role of Vitamin D to at least delaying the onset of Typ[e 2 diabetes.

Dodical jes Vitamin D-3 Cure Malignant Melanoma?: How about curry? VITAL information directly from meournals. (Collected Works: John A. McCormick Book 2) Kindle Edition

The mechanism of protection against melanoma cancers is not clear but the way Vitamin D helps prevent Type 2 diabetes is actually clear, the vitamin protects against β cell dysfunction

β cells have a profound effect on insulin sensitivity which is the real problem with diabetes.

Summary from Cell: "A primary cause of disease progression in type 2 diabetes (T2D) is β cell dysfunction due to inflammatory stress and insulin resistance. However, preventing β cell exhaustion under diabetic conditions is a major therapeutic challenge. Here, we identify the vitamin D receptor (VDR) as a key modulator of inflammation and β cell survival. Alternative recognition of an acetylated lysine in VDR by bromodomain proteins BRD7 and BRD9 directs association to PBAF and BAF chromatin remodeling complexes, respectively. Mechanistically, ligand promotes VDR association with PBAF to effect genome-wide changes in chromatin accessibility and enhancer landscape, resulting in an anti-inflammatory response. Importantly, pharmacological inhibition of BRD9 promotes PBAF-VDR association to restore β cell function and ameliorate hyperglycemia in murine T2D models. These studies reveal an unrecognized VDR-dependent transcriptional program underpinning β cell survival and identifies the VDR:PBAF/BAF association as a potential therapeutic target for T2D."
https://www.cell.com/cell/abstract/S0092-8674(18)30506-3
      Arnush, M.Heitmeier, M.R.Scarim, A.L.Marino, M.H.Manning, P.T.Corbett, J.A.
      IL-1 produced and released endogenously within human islets inhibits beta cell function.
      J. Clin. Invest. 1998; 102: 516-526
Figure thumbnail fx1
Illustration from Cell.com


Saturday, December 30, 2017

No critical discovery today but a look at healthy things to do. for the new year

No, this isn’t about getting more exercise. That’s important but everyone knows that.

COFFEE
More and more we are seeing reports that plain old coffee, a minimum of two cups a day, is very good for you.

Vitamin D-3
I wrote a booklet about the uses of Vitamin D-3 which is proven in clinical trials to help prevent or even treat malignant melanoma. The good news is that now that there are decent chemotherapy treatments (there weren’t when I contracted MM) you can also take massive doses of D-3 at the same time.

https://www.amazon.com/Does-Vitamin-Cure-Malignant-Melanoma-ebook/dp/B00LMHUP8W/ref=asap_bc?ie=UTF8

Turmeric
The spice which makes curry yellow and studies in India show it is a potent anti-cancer medicine. I take it with black pepper to improve absorption.

I don’t like curry, never have. But I take Turmeric/curcumin daily in capsules. Black pepper makes a good addition and in capsules, you’ll never taste it.

SPLENDA (Sucralose)
Its main benefit is that it has zero calories but it tastes to me and many people exactly like white sugar.

Generic brands are fine but powdered “splenda” has a lot of filler, about 95% filler. I use it occasionally but also buy the raw chemical in bulk mostly from Bulk Supplements on Amazon.

A tiny amount of the raw chemical is the equivalent of a cup of sugar and I’m talking a very tiny amount. My 100-gram package of sucralose is about the equivalent of 100 lbs of sugar.

LEARNING
Although the games promoted as helping prevent dementia and particularly Alzheimer's seem to be nonsense, there is strong evidence that learning something completely new such as a new language, a branch of science, etc. can build so many new connections in your brain that people who do that have been shown to show no symptoms of Alzheimer's but post-mortem examination of the brain showed they actually had advanced Alzheimer's,

Coconut Oil
A questionable connection has been made between brain nourishment and coconut oil. The good news is that coconut oil is perfectly safe to eat so why not give it a try.

The theory is that Alzheimer's causes insulin resistance in nerve cells, essentially starving them. Coconut oil uses a different transport method and can nourish those starved nerve cells.

There are reports that this effect is powerful and occurs just hours after consuming coconut oil (you can use it like butter or any cooking oil even in cookies). The improvement, when it occurs is temporary, only lasting hours, but, so what? It is easy to test and you can simply make coconut oil a part of the everyday diet Alzheimer's patients eat.

Q-10
Very important because as we get older a lot of medicines we take to deplete the body’s store of Q-10.

Vitamin C
There is accumulating evidence that Vitamin C is incredibly important and you should know that you can buy it by the kilogram for about $30. I use it in any food which needs some sour taste such as lemon pie.

BULK

If you aren’t satisfied with the mix of supplements on the market you can buy empty gel capsules and filler trays for mixes of bulk supplements.