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Thursday, August 16, 2018

New Sepsis Test Developed by UK MoD

With two revolutionary treatments for sepsis as described in other posts here in CMN, it becomes even more important to diagnose the deadly condition ASAP if ONLY so patient advocates have enough time to find a doctor who will listen to them about the new discoveries already saving lives in the few locations where they are being used.

Survival rates for sepsis aka blood poisoning drop nearly 10 percent each hour it goes undiagnosed and untreated.

The current test takes up to several days to give a full diagnosis of a disease which kills at least 5 million each year out of the approximately 30 million who contract it each year. 

That's more than bowel, breast, and prostate cancer combined.

Even more alarming is the fact that sepsis cases are increasing 10% each year.

In the UK it is believed to cost nearly £15 billion per year.

Now the United Kingdom's Ministry of Defense has announced a new rapid test to confirm sepsis, permitting faster treatment. 

Scientists at the Defence Science and Technology Laboratory (Dstl) in the UK have come up with a biomarker test which can prove the existence of a sepsis infection even before symptoms appear. The test is 97% accurate, having been studied for more than a decade.

Dr Roman Lukaszewski is the lead Dstl scientist.

Dstl site.

https://www.gov.uk/government/news/new-test-for-sepsis-could-improve-survival-rates-thanks-to-dstl-scientists

Friday, August 10, 2018

Vitamin D delays or prevents diabetes onset

My book on Vitamin D looked at the powerful medical journal evidence that Vitamin D-3 can prevent or cure malignant melanoma but the latest information expands the powerful role of Vitamin D to at least delaying the onset of Typ[e 2 diabetes.

Dodical jes Vitamin D-3 Cure Malignant Melanoma?: How about curry? VITAL information directly from meournals. (Collected Works: John A. McCormick Book 2) Kindle Edition

The mechanism of protection against melanoma cancers is not clear but the way Vitamin D helps prevent Type 2 diabetes is actually clear, the vitamin protects against β cell dysfunction

β cells have a profound effect on insulin sensitivity which is the real problem with diabetes.

Summary from Cell: "A primary cause of disease progression in type 2 diabetes (T2D) is β cell dysfunction due to inflammatory stress and insulin resistance. However, preventing β cell exhaustion under diabetic conditions is a major therapeutic challenge. Here, we identify the vitamin D receptor (VDR) as a key modulator of inflammation and β cell survival. Alternative recognition of an acetylated lysine in VDR by bromodomain proteins BRD7 and BRD9 directs association to PBAF and BAF chromatin remodeling complexes, respectively. Mechanistically, ligand promotes VDR association with PBAF to effect genome-wide changes in chromatin accessibility and enhancer landscape, resulting in an anti-inflammatory response. Importantly, pharmacological inhibition of BRD9 promotes PBAF-VDR association to restore β cell function and ameliorate hyperglycemia in murine T2D models. These studies reveal an unrecognized VDR-dependent transcriptional program underpinning β cell survival and identifies the VDR:PBAF/BAF association as a potential therapeutic target for T2D."
https://www.cell.com/cell/abstract/S0092-8674(18)30506-3
      Arnush, M.Heitmeier, M.R.Scarim, A.L.Marino, M.H.Manning, P.T.Corbett, J.A.
      IL-1 produced and released endogenously within human islets inhibits beta cell function.
      J. Clin. Invest. 1998; 102: 516-526
Figure thumbnail fx1
Illustration from Cell.com


Saturday, December 30, 2017

No critical discovery today but a look at healthy things to do. for the new year

No, this isn’t about getting more exercise. That’s important but everyone knows that.

COFFEE
More and more we are seeing reports that plain old coffee, a minimum of two cups a day, is very good for you.

Vitamin D-3
I wrote a booklet about the uses of Vitamin D-3 which is proven in clinical trials to help prevent or even treat malignant melanoma. The good news is that now that there are decent chemotherapy treatments (there weren’t when I contracted MM) you can also take massive doses of D-3 at the same time.

https://www.amazon.com/Does-Vitamin-Cure-Malignant-Melanoma-ebook/dp/B00LMHUP8W/ref=asap_bc?ie=UTF8

Turmeric
The spice which makes curry yellow and studies in India show it is a potent anti-cancer medicine. I take it with black pepper to improve absorption.

I don’t like curry, never have. But I take Turmeric/curcumin daily in capsules. Black pepper makes a good addition and in capsules, you’ll never taste it.

SPLENDA (Sucralose)
Its main benefit is that it has zero calories but it tastes to me and many people exactly like white sugar.

Generic brands are fine but powdered “splenda” has a lot of filler, about 95% filler. I use it occasionally but also buy the raw chemical in bulk mostly from Bulk Supplements on Amazon.

A tiny amount of the raw chemical is the equivalent of a cup of sugar and I’m talking a very tiny amount. My 100-gram package of sucralose is about the equivalent of 100 lbs of sugar.

LEARNING
Although the games promoted as helping prevent dementia and particularly Alzheimer's seem to be nonsense, there is strong evidence that learning something completely new such as a new language, a branch of science, etc. can build so many new connections in your brain that people who do that have been shown to show no symptoms of Alzheimer's but post-mortem examination of the brain showed they actually had advanced Alzheimer's,

Coconut Oil
A questionable connection has been made between brain nourishment and coconut oil. The good news is that coconut oil is perfectly safe to eat so why not give it a try.

The theory is that Alzheimer's causes insulin resistance in nerve cells, essentially starving them. Coconut oil uses a different transport method and can nourish those starved nerve cells.

There are reports that this effect is powerful and occurs just hours after consuming coconut oil (you can use it like butter or any cooking oil even in cookies). The improvement, when it occurs is temporary, only lasting hours, but, so what? It is easy to test and you can simply make coconut oil a part of the everyday diet Alzheimer's patients eat.

Q-10
Very important because as we get older a lot of medicines we take to deplete the body’s store of Q-10.

Vitamin C
There is accumulating evidence that Vitamin C is incredibly important and you should know that you can buy it by the kilogram for about $30. I use it in any food which needs some sour taste such as lemon pie.

BULK

If you aren’t satisfied with the mix of supplements on the market you can buy empty gel capsules and filler trays for mixes of bulk supplements.

Wednesday, November 8, 2017

WHY isn't cancer surgery treated as the emergency it is, like an appendix?

When I was diagnosed by my family physician as having a concerning mole and my dermatologist a week later as having melanoma, why did it take two more weeks to get it removed by the same dermatologist who had trained at Cleveland Clinic and even had papers published on malignant melanoma?

It was always my concern that one minute a cancer was localized and a minute later it started to metastasize and the patient was essentially terminal.

Since you don't know when that critical minute is, why isn't a suspected melanoma removed immediately - in other words, treated as the emergency it is? It is a simple local procedure.

Now a Cleveland Clinic study may cause some doctors to rethink this.

"The Cleveland Clinic study was published online recently in the Journal of the American Academy of Dermatology.
"The ideal timing for melanoma treatment, predominantly surgery, had yet to be determined -- until now," said primary investigator Dr. Brian Gastman. He is director of melanoma surgery at the Cleveland Clinic in Ohio.
"We saw significantly worse prognoses and outcomes for those surgically treated after 30 days of stage I melanoma diagnosis. Knowing for certain that a more expedient time to surgery to remove an early melanoma improves the chances of survival is a game-changer in treating this life-threatening skin cancer," Gastman said in a clinic news release.
Melanoma is on the rise in the United States. Nearly 162,000 new cases are expected to be diagnosed this year."
MY book about how I survived MM BEFORE there were any chemotherapy treatments which extended life even a month.
"Does Vitamin D-3 Cure MM?"  Obviously not but the clinical trials and summaries from Europe show why even now taking massive D-3 doses will improve your survival rate by up to 50%.





Tuesday, October 31, 2017

NEW GSK shingles vaccine much more effective

Glaxo Smith Kline received FDA approval for Shingrix a shingles vaccine which is much more effective for people over 60 and especially over 70.

The original vaccine was 70% effective for people in their 50's, 64% for those in their 60's, but only 41% effective for those in their 70's and almost useless for those over 80.

The new vaccine is 97% effective for 50-69 year olds and 91% effective for those over 70.

The new vaccine is better at preventing nerve pain after the shingles rash clears, nearly 90% effective.

Saturday, October 21, 2017

Simply AMAZING Alzheimer's symptomatic treatment

Dr.'s Newport and Veech are leading the fight to get a new Alzheimer's treatment into the mainstream.

First, this is NOT a treatment for Alzheimer's Disease (AD). Rather it is a way to alleviate some of the most critical symptoms - i.e. loss of mental capacity.

The entire basis of the treatment is linked to the fact that the physical changes in the brain caused by AD also make the brain cells (neurons) incapable of using insulin to transport sugar into the cell and the cells cease to function.

However while the cells can no longer use the glucose energy source, they can use ketone bodies for fuel bypassing the metabolic block which prevents them from using glucose.

When AD patients receive high doses of ketones the brain cells arfe no longer starved and begin to work again, sometimes amazingly quickly and well - showing improvements (in the approximately half of the cases where it works) within a few hours.

One way to increase the ketones in the bloodstream is to change to a diet which switches the body's metabolism from running on glucose from carbohydrates to one which burns body fat. Essentially the South Beach Diet.

Several people including Dr. Veech are working on supplements which produce a "therapeutic hyperketonemia" through the use of oral ingestion (eating) a strong ketogenic agent or ketone monoester (KME).

Trials of this treatment show, "The patient improved markedly in mood, affect, self-care, and cognitive and daily activity performance. The KME was well tolerated throughout the 20-month treatment period. Cognitive performance tracked plasma β-hydroxybutyrate concentrations, with noticeable improvements in conversation and interaction at the higher levels, compared with predose levels.
CONCLUSION:
--------------------------Information from  2015 Jan;11(1):99-103. doi: 10.1016/j.jalz.2014.01.006. Epub 2014 Oct 7.Newport MT1VanItallie TB2Kashiwaya Y3King MT4Veech RL5.

KME-induced hyperketonemia is robust, convenient, and safe, and the ester can be taken as an oral supplement without changing the habitual diet."
A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer's disease.
--------------------------

Many people go on a zero carb diet for two weeks or until your keto strips show your metabolism has switched from burning sugar to burning fat. You usually lose about 10 lbs pretty quickly.

This is actually a great diet, you eat eggs, bacon, pork, fish, lobster, butter, any cheese, cream, ice cream (homemade with sucralose (Splenda)), coffee, tea, almost anything except grains and tubers. Some veggies after the switch.but not most of them.

Coconut oil/butter is a good substitute for cooking oils and baking - it has very high levels of ketones.

You would think this meat and fat diet would cause your cholesterol to soar, but it actually lowers most people's cholesterol because cholesterol is just another fat which the body is now burning for energy.

The full text of the report is found at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300286/

Friday, October 13, 2017

CDC guides to pandemic preparedness

This pandemic warning may be unimportant but there is always that chance of a really big flu season. Remember, the equivalent of the 1918-19 Spanish Flu - that is, one for which few people have any immunity, would certainly kill upwards of 100 million since there is exactly ZERO useful treatment for such a virus.

All you can do is treat symptoms such as dehydration and when it gets really bad put the patient on a ventilator.

NCBI estimates there are 62,188 full mechanical ventilators in the U.S. 

Once all ventilators in a hospital are hooked up to patients (or vice versa) there is nothing further to do for really sick young or elderly flu patients.

CDC Guides