TWO SEPSIS/SEPTIC SHOCK CURES - also, a potential preventive pro-biotic dose

I have posted links to two medical treatments for sepsis which can save millions of lives (200,000 each year in U.S. alone) but there is also a newly discovered way to prevent sepsis in the first place which is vital for third-world countries. (SEE BELOW)

First Sepsis cure

The "Marik" Cure https://criticalmedicalnews.blogspot.com/2017/03/cure-for-sepsis-vitamin-c-and-steroids.html

Was discovered by a doctor Marik (who else), Dr. Paul Marik of the Eastern Virginia Medical School
https://www.ncbi.nlm.nih.gov/pubmed/27940189
uses just very safe Vitamin C, Thiamine, and hydrocortisone.

Demand the doctor treating your loved one - it is extremely safe and very inexpensive.

"Abstract

BACKGROUND:

The global burden of sepsis is estimated as 15 to 19 million cases annually, with a mortality rate approaching 60% in low-income countries.

METHODS:

In this retrospective before-after clinical study, we compared the outcome and clinical course of consecutive septic patients treated with intravenous vitamin C, hydrocortisone, and thiamine during a 7-month period (treatment group) with a control group treated in our ICU during the preceding 7 months. The primary outcome was hospital survival. A propensity score was generated to adjust the primary outcome.

RESULTS:

There were 47 patients in both treatment and control groups, with no significant differences in baseline characteristics between the two groups. The hospital mortality was 8.5% (4 of 47) in the treatment group compared with 40.4% (19 of 47) in the control group (P < .001). The propensity adjusted odds of mortality in the patients treated with the vitamin C protocol was 0.13 (95% CI, 0.04-0.48; P = .002). The Sepsis-Related Organ Failure Assessment score decreased in all patients in the treatment group, with none developing progressive organ failure. All patients in the treatment group were weaned off vasopressors, a mean of 18.3 ± 9.8 h after starting treatment with the vitamin C protocol. The mean duration of vasopressor use was 54.9 ± 28.4 h in the control group (P < .001).

CONCLUSIONS:

Our results suggest that the early use of intravenous vitamin C, together with corticosteroids and thiamine, are effective in preventing progressive organ dysfunction, including acute kidney injury, and in reducing the mortality of patients with severe sepsis and septic shock. Additional studies are required to confirm these preliminary findings.

Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved."

SECOND Sepsis cure

  https://criticalmedicalnews.blogspot.com/2016/05/sepsis-deaths-may-be-curbed-with.html

This treatment hasn't shown as many cures as the one using Vitamin C IV treatments but is also worth knowing about.

The treatment uses a very low dose of a chemotherapy drug - low enough that it has none of the side effects of the usual cancer treatment.

Now Molecular biologist Ivan Marazzi of the Ichan School of Medicine at Mount Sinai in New York City and colleagues have found that a chemotherapy drug, Camptothecin, can reduce mortality in septic mice by 90%.

This is, of course, an early animal test but since sepsis can and often does kill within hours even in a top hospital and there are few other treatments (and no really effective one) I would expect some doctors to use this FDA approved drug off label (perfectly legal) in a last ditch effort to prevent death.

Camptothecin’s cancer killing action is due to its blocking of the enzyme topoisomerase I, which, in part, seems to help orchestrate the immune system’s response.

Those patients who already have an influenza infection are particularly at risk to bacterial infection triggered sepsis.

According to Science Magazine, immunopathologist Peter Ward of the University of Michigan, Ann Arbor, molecular biologist Murat Kaynar of the University of Pittsburgh School of Medicine in Pennsylvania and others find these tests extremely interesting although they caution against putting too much faith in these early results.

In addition to the fact that there is really no other good method of treating advanced sepsis, the powerful chemotherapy drug would only need to be given in relatively small amounts - far less than in treating cancer.

(http://www.sciencemag.org/news/2016/04/fighting-sepsis-cancer-drugs?utm_campaign=news_daily_2016-04-28&et_rid=17098693&et_cid=453390)

Septic shock prevention

I am not going into any details since it isn't a simple treatment, but it will be important in preventing the sepsis death of many of the 60,000 children who die of septic shock each year around the world.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296993/

Dr Pinaki Panigrahi, a pediatrician searched for 20 years to find out the probiotic bacteria, common in kimchi, pickles and other fermented vegetables, which protects people against septic shock.

The pro-biotic he found is Lactobacillus plantarum.