Low carb AND high carb diets increase chance of early death - Lancet published study

A study of 15,000 adults age 45-64 in 4 US communities who were part of the Atherosclerosis Risk in Communities study between 1987 and 1989 and weren't on any extreme caloric diet, either high or low, was recently used as the basis of a follow up 25 years later.

By now there have been 6,283 deaths in the ARIC group but the study in The Lancet Public Health also looked at more than 400,000 people in other studies.

Those who had the lowest risk of mortality (death) from all causes were the ones who got about half of their calories from carbohydrates.

BOTH low carb <40% and high carb >70% diets resulted in greater risk of early death.

In addition, if the carbs were replaced by animal fat or animal protein the risk was also higher but if the carbs were replaced by plant-based oils or protein.

The study was recently published in The Lancet Public Health which is available online.

New Sepsis Test Developed by UK MoD

With two revolutionary treatments for sepsis as described in other posts here in CMN, it becomes even more important to diagnose the deadly condition ASAP if ONLY so patient advocates have enough time to find a doctor who will listen to them about the new discoveries already saving lives in the few locations where they are being used.

Survival rates for sepsis aka blood poisoning drop nearly 10 percent each hour it goes undiagnosed and untreated.

The current test takes up to several days to give a full diagnosis of a disease which kills at least 5 million each year out of the approximately 30 million who contract it each year. 

That's more than bowel, breast, and prostate cancer combined.

Even more alarming is the fact that sepsis cases are increasing 10% each year.

In the UK it is believed to cost nearly £15 billion per year.

Now the United Kingdom's Ministry of Defense has announced a new rapid test to confirm sepsis, permitting faster treatment. 

Scientists at the Defence Science and Technology Laboratory (Dstl) in the UK have come up with a biomarker test which can prove the existence of a sepsis infection even before symptoms appear. The test is 97% accurate, having been studied for more than a decade.

Dr Roman Lukaszewski is the lead Dstl scientist.

Dstl site.

https://www.gov.uk/government/news/new-test-for-sepsis-could-improve-survival-rates-thanks-to-dstl-scientists

Vitamin D delays or prevents diabetes onset

My book on Vitamin D looked at the powerful medical journal evidence that Vitamin D-3 can prevent or cure malignant melanoma but the latest information expands the powerful role of Vitamin D to at least delaying the onset of Typ[e 2 diabetes.

Dodical jes Vitamin D-3 Cure Malignant Melanoma?: How about curry? VITAL information directly from meournals. (Collected Works: John A. McCormick Book 2) Kindle Edition

The mechanism of protection against melanoma cancers is not clear but the way Vitamin D helps prevent Type 2 diabetes is actually clear, the vitamin protects against β cell dysfunction

β cells have a profound effect on insulin sensitivity which is the real problem with diabetes.

Summary from Cell: "A primary cause of disease progression in type 2 diabetes (T2D) is β cell dysfunction due to inflammatory stress and insulin resistance. However, preventing β cell exhaustion under diabetic conditions is a major therapeutic challenge. Here, we identify the vitamin D receptor (VDR) as a key modulator of inflammation and β cell survival. Alternative recognition of an acetylated lysine in VDR by bromodomain proteins BRD7 and BRD9 directs association to PBAF and BAF chromatin remodeling complexes, respectively. Mechanistically, ligand promotes VDR association with PBAF to effect genome-wide changes in chromatin accessibility and enhancer landscape, resulting in an anti-inflammatory response. Importantly, pharmacological inhibition of BRD9 promotes PBAF-VDR association to restore β cell function and ameliorate hyperglycemia in murine T2D models. These studies reveal an unrecognized VDR-dependent transcriptional program underpinning β cell survival and identifies the VDR:PBAF/BAF association as a potential therapeutic target for T2D."

https://www.cell.com/cell/abstract/S0092-8674(18)30506-3

Arnush, M.Heitmeier, M.R.Scarim, A.L.Marino, M.H.Manning, P.T.Corbett, J.A.
IL-1 produced and released endogenously within human islets inhibits beta cell function.
J. Clin. Invest. 1998; 102: 516-526

Illustration from Cell.com