TWO SEPSIS/SEPTIC SHOCK CURES - also, a potential preventive pro-biotic dose

I have posted links to two medical treatments for sepsis which can save millions of lives (200,000 each year in U.S. alone) but there is also a newly discovered way to prevent sepsis in the first place which is vital for third-world countries. (SEE BELOW)

First Sepsis cure

The "Marik" Cure https://criticalmedicalnews.blogspot.com/2017/03/cure-for-sepsis-vitamin-c-and-steroids.html

Was discovered by a doctor Marik (who else), Dr. Paul Marik of the Eastern Virginia Medical School
https://www.ncbi.nlm.nih.gov/pubmed/27940189
uses just very safe Vitamin C, Thiamine, and hydrocortisone.

Demand the doctor treating your loved one - it is extremely safe and very inexpensive.

"Abstract

BACKGROUND:

The global burden of sepsis is estimated as 15 to 19 million cases annually, with a mortality rate approaching 60% in low-income countries.

METHODS:

In this retrospective before-after clinical study, we compared the outcome and clinical course of consecutive septic patients treated with intravenous vitamin C, hydrocortisone, and thiamine during a 7-month period (treatment group) with a control group treated in our ICU during the preceding 7 months. The primary outcome was hospital survival. A propensity score was generated to adjust the primary outcome.

RESULTS:

There were 47 patients in both treatment and control groups, with no significant differences in baseline characteristics between the two groups. The hospital mortality was 8.5% (4 of 47) in the treatment group compared with 40.4% (19 of 47) in the control group (P < .001). The propensity adjusted odds of mortality in the patients treated with the vitamin C protocol was 0.13 (95% CI, 0.04-0.48; P = .002). The Sepsis-Related Organ Failure Assessment score decreased in all patients in the treatment group, with none developing progressive organ failure. All patients in the treatment group were weaned off vasopressors, a mean of 18.3 ± 9.8 h after starting treatment with the vitamin C protocol. The mean duration of vasopressor use was 54.9 ± 28.4 h in the control group (P < .001).

CONCLUSIONS:

Our results suggest that the early use of intravenous vitamin C, together with corticosteroids and thiamine, are effective in preventing progressive organ dysfunction, including acute kidney injury, and in reducing the mortality of patients with severe sepsis and septic shock. Additional studies are required to confirm these preliminary findings.

Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved."

SECOND Sepsis cure

  https://criticalmedicalnews.blogspot.com/2016/05/sepsis-deaths-may-be-curbed-with.html

This treatment hasn't shown as many cures as the one using Vitamin C IV treatments but is also worth knowing about.

The treatment uses a very low dose of a chemotherapy drug - low enough that it has none of the side effects of the usual cancer treatment.

Now Molecular biologist Ivan Marazzi of the Ichan School of Medicine at Mount Sinai in New York City and colleagues have found that a chemotherapy drug, Camptothecin, can reduce mortality in septic mice by 90%.

This is, of course, an early animal test but since sepsis can and often does kill within hours even in a top hospital and there are few other treatments (and no really effective one) I would expect some doctors to use this FDA approved drug off label (perfectly legal) in a last ditch effort to prevent death.

Camptothecin’s cancer killing action is due to its blocking of the enzyme topoisomerase I, which, in part, seems to help orchestrate the immune system’s response.

Those patients who already have an influenza infection are particularly at risk to bacterial infection triggered sepsis.

According to Science Magazine, immunopathologist Peter Ward of the University of Michigan, Ann Arbor, molecular biologist Murat Kaynar of the University of Pittsburgh School of Medicine in Pennsylvania and others find these tests extremely interesting although they caution against putting too much faith in these early results.

In addition to the fact that there is really no other good method of treating advanced sepsis, the powerful chemotherapy drug would only need to be given in relatively small amounts - far less than in treating cancer.

(http://www.sciencemag.org/news/2016/04/fighting-sepsis-cancer-drugs?utm_campaign=news_daily_2016-04-28&et_rid=17098693&et_cid=453390)

Septic shock prevention

I am not going into any details since it isn't a simple treatment, but it will be important in preventing the sepsis death of many of the 60,000 children who die of septic shock each year around the world.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296993/

Dr Pinaki Panigrahi, a pediatrician searched for 20 years to find out the probiotic bacteria, common in kimchi, pickles and other fermented vegetables, which protects people against septic shock.

The pro-biotic he found is Lactobacillus plantarum.

Migraine relief from blowing in ear

Migraine headaches are, along with actual back pain (not the fakers looking for opioids), the biggest unsolved problems in pain management for more people than anything else.

Preventing migraine attacks has long been the goal of many researchers and now it appears there may be a simple solution - alternating warm and cool air blown gently into the ear canal.

"Preventing Episodic Migraine With Caloric Vestibular Stimulation: A Randomized Controlled Trial"

"Objective

To evaluate the safety and efficacy of a novel solid-state, caloric vestibular stimulation (CVS) device to provide adjuvant therapy for the prevention of episodic migraine in adult migraineurs.

Background

Migraine causes significant disability in ∼12% of the world population. No current migraine preventive treatment provides full clinical relief, and many exhibit high rates of discontinuation due to adverse events. Thus, new therapeutic options are needed. CVS may be an effective and safe adjuvant-therapy for the prevention of episodic migraine.

Methods

In a multicenter, parallel-arm, block-randomized, placebo-controlled clinical trial (clinicaltrials.gov: NCT01899040), subjects completed a 3-month treatment with the TNM™ device for CVS (refer to Fig. 2 for patient enrollment and allocation). The primary endpoint was the change in monthly migraine days from baseline to the third treatment month. Secondary endpoints were 50% responder rates, change in prescription analgesic usage and difference in total subjective headache-related pain scores. Device safety assessments included evaluation of any impact on mood, cognition, or balance.

Conclusion

The TNM™ device for CVS appears to provide a clinically efficacious and highly tolerable adjuvant therapy for the prevention of episodic migraine."

Quote from Vital Updates, "Cool and warm currents pumped through headphones to the ear canal could be an effective migraine prevention tool in the near future.

Led by David Wilkinson at the University of Kent, volunteers participated in a migraine study using caloric vestibular stimulation (CVS). By stimulating balance organs, CVS is thought to change brainstem activity, which is linked to migraine onset. The study’s objective was to evaluate the safety and efficacy of a novel CVS device in order to provide therapy for the prevention of episodic migraines in adults."

$200 medical Tricorder will soon be available if FDA releases it

The Star Trek Tricorder is here, 250 years early

Sorry, I'm prevented from posting my story here but follow this link to my own story on Blasting News.

http://uk.blastingnews.com/health/2017/04/the-star-trek-tricorder-is-here-250-years-early-001652257.html

UPDATE - SEPSIS CURE cheap and safe!

Sepsis (blood poisoning) kills 250,000 each year - last year it killed actress Patty Duke.

Now there are two simple, easy treatments/cures for septic shock.

The Marik protocol could be an incredible breakthrough for third-world countries because it is so easy and inexpensive. 

Dr. Paul Marik of Eastern Virginia Medical School tried acombination of IV Vitamin C (Ascorbic Acid) and a hydrocortisone steroid on 150sepsis patients, ALL recovered. total cost of medicine in treatment $60. Inmost of the cases he added the vitamin B1 (thiamin) to increase the absorptionof vitamin C.

1 pound of ascorbic acid USP costs $12 or $25/Kilo.

http://www.evms.edu/pulse/archive/chancediscoverycouldsavemillionsfromsepsis.php

There have been many complaints that there has been no clinical trial of this protocol but none of them mention that there is no evidence that the $60 treatment has any potential to do harm.

Ethically how can any doctor refuse to try this treatment when sepsis kills so many people?

Sepsis is the body's reaction to an infection and the Marik protocol doesn't treat the underlying infection, rather it keeps the patient alive long enough that doctors can determine the correct treatment for the infection.

Septic shock kills so quickly that doctors often can't treat the underlying infection quickly enough.

SECOND TREATMENT

If that isn't enough, there is a second new sepsis protocol makes use of a very small dose of a common chemotherapy drug. See my earlier posting here.